An Entropic Mechanism of Generating Selective Ion Binding in Macromolecules
نویسندگان
چکیده
منابع مشابه
An Entropic Mechanism of Generating Selective Ion Binding in Macromolecules
Several mechanisms have been proposed to explain how ion channels and transporters distinguish between similar ions, a process crucial for maintaining proper cell function. Of these, three can be broadly classed as mechanisms involving specific positional constraints on the ion coordinating ligands which arise through: a "rigid cavity", a 'strained cavity' and 'reduced ligand fluctuations'. Eac...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2013
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1002914